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Piccirilli, Joseph A.

One or more keywords matched the following items that are connected to Piccirilli, Joseph A.

Item Type	Name
Concept	Catalysis
Concept	Chemistry, Physical
Concept	Enzymes
Concept	Enzyme Assays
Academic Article	RNA catalysis by a group I ribozyme. Developing a model for transition state stabilization.
Academic Article	Metal ion catalysis in the Tetrahymena ribozyme reaction.
Academic Article	Three metal ions at the active site of the Tetrahymena group I ribozyme.
Academic Article	Do enzymes obey the Baldwin rules? A mechanistic imperative in enzymatic cyclization reactions.
Academic Article	Synthesis of 3'-thioribonucleosides and their incorporation into oligoribonucleotides via phosphoramidite chemistry.
Academic Article	Metal ion catalysis during splicing of premessenger RNA.
Academic Article	Metal ion coordination by the AGC triad in domain 5 contributes to group II intron catalysis.
Academic Article	Leaving group stabilization by metal ion coordination and hydrogen bond donation is an evolutionarily conserved feature of group I introns.
Academic Article	The role of the cleavage site 2'-hydroxyl in the Tetrahymena group I ribozyme reaction.
Academic Article	Metal ion catalysis during group II intron self-splicing: parallels with the spliceosome.
Academic Article	Metal ion catalysis during the exon-ligation step of nuclear pre-mRNA splicing: extending the parallels between the spliceosome and group II introns.
Academic Article	Enzymatic incorporation of a new base pair into DNA and RNA extends the genetic alphabet.
Academic Article	A C-nucleotide base pair: methylpseudouridine-directed incorporation of formycin triphosphate into RNA catalyzed by T7 RNA polymerase.
Academic Article	Identification of an active site ligand for a group I ribozyme catalytic metal ion.
Academic Article	Redesigning nucleic acids.
Academic Article	The tetrahymena ribozyme cleaves a 5'-methylene phosphonate monoester approximately 10(2)-fold faster than a normal phosphate diester: implications for enzyme catalysis of phosphoryl transfer reactions.
Academic Article	Synthesis of 2'-C-difluoromethylribonucleosides and their enzymatic incorporation into oligonucleotides.
Academic Article	General acid catalysis by the hepatitis delta virus ribozyme.
Academic Article	Synthesis and biochemical application of 2'-O-methyl-3'-thioguanosine as a probe to explore group I intron catalysis.
Academic Article	Identification of catalytic metal ion ligands in ribozymes.
Academic Article	Structure and function converge to identify a hydrogen bond in a group I ribozyme active site.
Academic Article	Efficient chemical synthesis of AppDNA by adenylation of immobilized DNA-5'-monophosphate.
Academic Article	Crystal structure of the catalytic core of an RNA-polymerase ribozyme.
Academic Article	Nucleotide analogues to investigate RNA structure and function.
Academic Article	Nucleobase-mediated general acid-base catalysis in the Varkud satellite ribozyme.
Academic Article	2'-amino-modified ribonucleotides as probes for local interactions within RNA.
Academic Article	Linkage between substrate recognition and catalysis during cleavage of sarcin/ricin loop RNA by restrictocin.
Academic Article	Functional identification of ligands for a catalytic metal ion in group I introns.
Academic Article	Thermodynamic evidence for negative charge stabilization by a catalytic metal ion within an RNA active site.
Academic Article	The mechanism of peptidyl transfer catalysis by the ribosome.
Academic Article	Synthesis of 2'-N-methylamino-2'-deoxyguanosine and 2'-N,N-dimethylamino-2'-deoxyguanosine and their incorporation into RNA by phosphoramidite chemistry.
Academic Article	Crystal structure of an RNA polymerase ribozyme in complex with an antibody fragment.
Academic Article	Modulation of individual steps in group I intron catalysis by a peripheral metal ion.
Academic Article	Separation of RNA phosphorothioate oligonucleotides by HPLC.
Academic Article	Kinetic characterization of the second step of group II intron splicing: role of metal ions and the cleavage site 2'-OH in catalysis.
Academic Article	Defining the catalytic metal ion interactions in the Tetrahymena ribozyme reaction.
Academic Article	New strategies for exploring RNA's 2'-OH expose the importance of solvent during group II intron catalysis.
Academic Article	Functional identification of catalytic metal ion binding sites within RNA.
Academic Article	A rearrangement of the guanosine-binding site establishes an extended network of functional interactions in the Tetrahymena group I ribozyme active site.
Academic Article	General acid-base catalysis mediated by nucleobases in the hairpin ribozyme.
Academic Article	Altered (transition) states: mechanisms of solution and enzyme catalyzed RNA 2'-O-transphosphorylation.
Academic Article	RNA catalyses nuclear pre-mRNA splicing.
Academic Article	Synthesis and incorporation of the phosphoramidite derivative of 2'-O-photocaged 3'-s-thioguanosine into oligoribonucleotides: substrate for probing the mechanism of RNA catalysis.
Academic Article	Enzyme transition states from theory and experiment.
Academic Article	Effect of Zn2+ binding and enzyme active site on the transition state for RNA 2'-O-transphosphorylation interpreted through kinetic isotope effects.
Academic Article	An active site rearrangement within the Tetrahymena group I ribozyme releases nonproductive interactions and allows formation of catalytic interactions.
Academic Article	Isotope effect analyses provide evidence for an altered transition state for RNA 2'-O-transphosphorylation catalyzed by Zn(2+).
Academic Article	Reverse transcriptases lend a hand in splicing catalysis.
Academic Article	Efficient Synthetic Approach to Linear Dasatinib-DNA Conjugates by Click Chemistry.
Academic Article	Incorporation of 2'-Deoxy-2'-mercaptocytidine into Oligonucleotides via Phosphoramidite Chemistry.
Academic Article	Kinetic Isotope Effect Analysis of RNA 2'-O-Transphosphorylation.
Academic Article	An Ontology for Facilitating Discussion of Catalytic Strategies of RNA-Cleaving Enzymes.
Academic Article	The L-platform/L-scaffold framework: a blueprint for RNA-cleaving nucleic acid enzyme design.
Academic Article	Structural basis for substrate binding and catalysis by a self-alkylating ribozyme.
Academic Article	Dissociative Transition State in Hepatitis Delta Virus Ribozyme Catalysis.
Academic Article	Rapid Kinetics of Pistol Ribozyme: Insights into Limits to RNA Catalysis.

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chemistry
enzyme
catalysis